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326 Astrocytes regulate glutamate presence in the interstitium, 327 tune neuronal excitability through K + buffering, 328 and influence inhibitory/excitatory balance through tonic release of GABA 329 and by supplying Cl - to inhibitory synapses

However, further studies with sophisticated isotope tracing have shown that DNL plays a larger role in NAFLD patients than previously suggested 47,48,49

Moreover, CB-839 can treat tumors synergistically in combination with other targeted tumor inhibitors, making it the most likely GLS1 inhibitor for clinical use in the future