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It is important to note that pyroptosome is not necessary for the execution of pyroptosis, which can occur by NLRC4 dependent Caspase-1 activation [92]

doi: 10.3389/fphar.2021.789570 Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022)

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These discordant findings may reflect the much lower activity of GFAT in freshly isolated compared to cultured ECs, which may be insufficient to compromise NADPH levels [68]

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