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Oral bioavailability and BBB permeability: CSF1Ri compounds exhibit good oral activity and brain penetration, enabling long-term and reversible microglial depletion, which facilitates in-depth studies of microglial roles in neurodevelopment, homeostasis, and disease

Large-scale clinical studies are needed before definitive conclusions can be drawn

SMA-positivity was associated with improved long-term cancer survival, though further studies are needed to investigate this effect

De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function

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In accord with these results, TSC2 protein levels determined immunohistochemically were higher in hypertrophic chondrocytes of the CartIR / mice compared to controls (Figure 5b)