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NAFLD, increasingly prevalent in the context of rising obesity rates, involves fat accumulation in liver cells without significant alcohol consumption and can progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and liver failure [3]

The redox cycling enzymes thioredoxin, thioredoxin reductase, sulfiredoxin, peroxiredoxin, GSH peroxidase, superoxide dismutase 1, and catalase, and several GSH S-transferases, which are the enzymes mediating the elimination of ROS, are all Nrf2 targets (242)

OladosuWOLawaniOAOyewoRAOderinuKAJimohOSMotayoBOet al

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Mechanistically, the induction of ferroptosis is intricately associated with an imbalance between the oxidative and antioxidant systems within the organism

Prtoric, H