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Females showed much milder disease in both genotypes with a trend to decreased plaque burden in both descending aorta and aortic arch (Supplementary Figure S1)

Additionally, anti-inflammatory cytokine IL-10 plays a critical role in maintaining intestinal homeostasis by preserving intestinal barrier integrity

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In contrast, iron supplementation had no significant impact on lesion progression in this model, likely due to the intrinsic resistance of EMS lesions to iron overload-induced ferroptosis

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