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Emerging research suggests probiotics may support digestive health and immune function while indirectly supporting liver health, although more canine-specific studies are needed

10.1111/j.1600-065x.2011.01074.x 290 WhiteM

Zhang, L.-J

With aging, multiple structural and functional alterations such as decreased cerebrovascular pulsatility, reduced aquaporin-4 polarization on astrocyte end feet, and impaired perivascular cerebrospinal fluid exchange significantly reduce glymphatic efficiency

In metabolic disease, nutrient overload and ER stress elevate H 2 O 2 /O 2 , coupling lipotoxicity to ferroptotic risk when labile iron expands (Schieber and Chandel 2014)

Furthermore, curcumins antioxidant action protects oral mucosal cells from therapy-induced oxidative stress, and its anti-microbial effect may help prevent secondary infections of ulcerated mucosa (Amatto et al., 2025)