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AOD-9604 produces fat loss without any IGF-1 elevation, preserves normal glucose metabolism and insulin sensitivity, does not promote muscle growth or tissue proliferation, shows minimal fluid retention or edema, and requires less intensive monitoring due to absence of systemic effects

If a rash, hives, swelling, or trouble breathing shows up, stop use immediately and seek medical care

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5-Amino-1MQ was developed as a pharmacological tool to inhibit NNMT activity, and preclinical studies have demonstrated that oral administration of 5-Amino-1MQ to obese rodents produces dose-dependent reductions in body weight and fat mass, improvements in glucose metabolism and insulin sensitivity, and increases in energy expenditure - remarkably, these effects occur without changes in food intake, indicating that 5-Amino-1MQ works through metabolic enhancement and increased caloric burn rather than appetite suppression

doi: 10.1385/1-59259-922-2:191