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These effects are established during developmental time slots when the system is primed for staged development during gestation and the perinatal period

Lin X, Nelson WG (2003) Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells

Lower energy, sluggish recovery, reduced metabolic efficiency, and a general sense that your body isn't bouncing back the way it used to

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I think that's a good empirical way of thinking about it