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Metal ion-based multifunctional nanomaterials demonstrate significant potential for theranostics integration through precise modulation of the tumor microenvironment, enhancement of radiosensitivity, and activation of immune responses

Pelegrin, P

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Acknowledgements R.A.E

Structurally, in addition to the effects of hypoxia in pBOO (Stephany et al., 2013), mechanical traction elevates inflammatory mediators such as nuclear factor kappa-B (NF-B), tumor necrosis factor (TNF)-, and interleukin (IL)-6 (Drzewiecki et al., 2012), while ischemia-reperfusion increases oxidative stress in bladder tissue, leading to a surge in reactive oxygen species (ROS) (Miyata et al., 2019)

They play essential roles in: Brain function and cognition 2 Bone density and fracture prevention Cardiovascular and metabolic health Muscle mass and body composition Skin, hair, and connective tissue integrity Emotional regulation and sleep quality 3 Research shows that prolonged estrogen deficiency affects multiple organ systems, contributing not only to disruptive symptoms but also to increased long-term health risks, including osteoporosis and cognitive decline