female network oral glutathione Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity: Cell The effects of the – Seeking Health Glutathione Plus, 100

d 5 -JA was added to the extraction solvent (isopropanol: formic acid at 99.5: 0.5, v/v) as internal standard

Animal model research demonstrated that depleting GSH via inhibition of GCL triggered a cascade of lipid peroxidation and cell death in mesencephalic cultures, identifying oxidative stress from glutathione insufficiency as a likely initiating mechanism in neurodegeneration

Disclosures: Kezia Hobson: Perspectum Ltd: Employee, Dylan Windell: Perspectum: Employee, asd: Employee, Paul Aljabar: Nothing to Disclose, George Ralli: Nothing to Disclose, Rob Goldin: Nothing to Disclose, Kenneth Fleming: Nothing to Disclose, Caitlin Langford: Nothing to Disclose 775 HISTOLOGICAL DIAGNOSTIC TOOL FOR DETECTING AND CHARACTERISING PORTAL TRACTS IN LIVER DISEASE USING ARTIFICIAL INTELLIGENCE Dylan Windell 1 Alastair Magness 1 Abhishek Roy 1 Paul Aljabar 1 Timothy Kendall 2 Eve Fryer 3 Kenneth Fleming 4 Rob Goldin 5 Caitlin Langford 1 , 1 Perspectum, 2 University of Edinburgh, 3 Oxford University Hospitals NHS, 4 University of Oxford, 5 Imperial College London Background: AI- driven digital workflows for liver biopsy grading and staging have the potential to produce more accurate and reproducible results than traditional assessments

Rhee SG, Yang KS, Kang SW, Woo HA, Chang TS

In the combination therapy with PD-1 blockade, biomarker levels were markedly enhanced compared with monotherapy

Moving toward a systems-level understanding, empowered by interactomics, CRISPR technologies, AI-driven modeling and precision biomarker science, will profoundly transform how we interpret disease biology and develop therapeutics