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doi:10.1074/jbc.M707915200 pmid:17962183 Junger WG (2011) Immune cell regulation by autocrine purinergic signalling

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The binding mode of tadalafil shows some similarities to that of sildenafil, where the beta-carboline core of tadalafil forms CH-pi interactions with Phe820 and Val782, as well as hydrophobic interactions with Val782 and Tyr612

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Andreeff M , Melamed MR, Miller D, Clarkson BD