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The hydrogen bonding with chain A at Gly-121 on the backbone of TNF- allowed for docking, and the sugar molecule also demonstrated hydrogen bonding with chain A at Tyr-59

Neurochem Int 57:906913

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Furthermore, a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects was conducted