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Pro-inflammatory cytokines, COX-2, and inducible nitric oxide synthase (iNOS) levels as well as glial fibrillary acidic protein are reduced on consumption of hesperidin (Sakata, Hirose, Qiao, Tanaka, & Mori, 2003)

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Figure 3 8.2 Relative stability and dynamic equilibrium of the tophi microenvironment Mature tophi function as relatively independent immune microenvironments, defined by distinctive physicochemical characteristics such as low pH and hypoxia

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Also contact your physician urgently if you develop fever with spreading redness beyond 2 cm from an injection site (possible infection), persistent severe headaches unrelieved by hydration, vision changes, or sustained rapid heartbeat