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Cognitive improvement was observed after 8 weeks of treatment in both females and males, sustained through a 12-week study period, and accompanied by a concurrent reduction in amyloid plaques and neuroinflammation compared to intranasal saline-treated transgenic mice

Because oral glutathione supplements have historically demonstrated poor bioavailability and are rapidly broken down by enzymes in the gastrointestinal tract, the body relies heavily on intracellular de novo synthesis to maintain its protective antioxidant pools

NPs offer several advantages, such as customizable surface properties, cross the BBB, targeted drug delivery, and enhanced absorption

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Surgery is invasive, Low Wang said

Dose adjustments of these agents are likely to be necessary under medical supervision