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Bioactivity was determined using an IGF-1-responsive firefly luciferase reporter assay

Nutrient-dependent mTORC1 association with the ULK1Atg13FIP200 complex required for autophagy

Almost three quarters of the CD8+ T cells from this patient were TEMRAs, which are senescent T cells with poor proliferative potential associated with poor survival in cancer patients ( Figure 4 A gradual re-emergence of TEM and proportionate reduction of TEMRA was evident at tp1 and tp2 ( Figure 4A

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