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It has a variety of side effects that range from mild to moderate and sometimes serious

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So, if your vitamin B12 is not working properly because your folate metabolism isnt working properly this causes homocysteine imbalances which are considered a serious health problem for anyone especially for those with MTHFR gene mutations. 4 Reactions to Methylfolate supplementation Individuals that cannot tolerate Methylfolate often have low B12 levels in their cells

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B12 is essential in many vital functions in the body, so when choosing which B12 supplement, it's important to ensure you are taking the active, bioavailable forms