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At more permissive thresholds that detect 90% of pathogenic variants, fully ~ 30% of pathogenicity predictions were erroneous [6]

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In the initial larger, higher resolution, dataset of Cagri-CTR-Gs ( N = 1), density was observed for the proximal region of the conjugated lipid at the peptide N-terminus that was consistent regardless of peptide conformation (bypass or CT-like) and supports modelling the Glu linker and a short segment of acyl chain in a different orientation to that observed in the AMY 1 R complex (Figs