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5 Macrophage-derived exosomes: the command center of immunometabolic reprogramming Alveolar macrophages (AMs) are not only the first line of defense in pulmonary immune defense but also key cells that perceive danger signals and initiate responses during the pathological progression of sepsis-associated ARDS (67)

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Protein lysates were resolved by SDSPAGE electrophoresis (Invitrogen sure-lock system and Nu-PAGE 4-12% Bis-Tris precast gels)