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Without robust blood flow, the disc's ability to repair itself is profoundly limited

The base mechanism is identical, so if the modified versions really do achieve substantially higher effective tissue concentrations per administered milligram, then a lower administered dose makes sense

doi: 10.1016/j.cell.2006.01.007 94 MaR-YBlackAQianB-Z

Tastuzawa Y, Sekinaka K, Suda T, Matsumoto H, Otabe H, Nonoyama S, et al

The effect is reproducible but typically not dose-defining relative to other covariates (e.g., albumin, tumor burden, time varying clearance)

The PBT-CBT-gradient provides a reliable measure for inner heat conductance and predicts the increase in N3