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doi: 10.1016/j.micres.2025.128102 48 LiuS.AnY.CaoB.SunR.KeJ.ZhaoD

Efferocytosis rewires amino acid metabolism pathways Untargeted LC-MS of LPS-primed peritoneal macrophages fed with either apoptotic, necrotic or IgG coated Jurkat cells ex vivo, showed that upon engulfment of any target cell, amino acid content increases, including methionine, arginine and lysine [80]

High cortisol levels can also cause you to overeat, which can lead to weight gain and lowered testosterone

The small-molecule inhibitors milademetan (RAIN-32) 348 and brigimadlin (BI 907828) 349 are being evaluated in patients with wild-type TP53 , MDM2 -amplified biliary tract cancer in the MANTRA-2 (NCT05012397) and BRIGHTLINE-2 (NCT05512377) basket studies, respectively

Eur J Drug Metab Pharmacokinet 43:239249 Nascimento LRC, Tambwe PM, Carvalho GAd, Zanchi FB, Neves BJ, Ulrich H, Pinto MCX (2026) In silico analysis of the multitarget potential of GlyT1 inhibitors in SLC6 transporters