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doi: 10.1007/s12020-011-9472-3 34 BartalenaLTandaMLPiantanidaELaiA

HBP activity exerts context-dependent effects: acute activation may offer cardioprotection, whereas chronic HBP upregulation under hyperglycemia induces endoplasmic reticular (ER) stress, lipid accumulation, and inflammation [72]

Specifically, intracellular GSH levels (Fig S6e) and Chac2 expression (Fig S6f) remained unchanged in Lig-Ifnar1 / neutrophils compared to controls

The liver is the primary target organ for iron overload, and notable iron accumulation led to liver dysfunction in this patient

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