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Instead, it is a combination of diet and environment, which interacts with increased susceptibility due to the MTHFR variants

A reliable biomarker of oxidative stress must fulfill the following criteria: (a) clinical relevance (b) specificity for certain diseases (c) reflect the stage of the disease (d) quantification of the biomarkers should show a high degree of reproducibility

10.1371/journal.pone.0020827 188 ZhangW.-J.WeiH.FreiB

For instance, the accumulation of LDs and colocalization with Beclin-1 or LC3 has been reported in aging brain cells including the microglia, astrocytes, neurons, and ventricular tract cells [89]

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