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The hallmark symptom of a kidney stone lodged in or obstructing a ureter is severe flank pain that comes on suddenly and is distinctly one-sided

In addition, prior studies have shown that inhibiting the ACBP system in vivo, whether by neutralizing extracellular ACBP, knocking out the Dbi gene (thus removing both intra- and extracellular ACBP), or mutating the ACBP receptor (thus affecting only signaling by extracellular ACBP), provides comparable protection against liver damage induced by methionine-choline deficiency 35 , hepatic steatosis triggered by high-fat diets 32,51 , and high-dose corticotherapy-induced metabolic shifts leading to visceral obesity, steatosis, dyslipidemia and insulin resistance 52

Mitochondria in health and disease

NAFLD is initiated by lipid accumulation in hepatocytes, which leads to a spectrum of liver dysfunction ranging from excess lipid storage (hepato-steatosis) to progressive NASH, that in turn increases the risk for cirrhosis and HCC

Can conclusions drawn from animal studies sufficiently support translation to human pathophysiology

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