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Differential requirements for l-citrulline and l-arginine during antimycobacterial macrophage activity

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In mammalian cells NAD + is synthesized by three main pathways: (i) de novo biosynthesis pathway, through the Kynurenine pathway, where tryptophan as the precursor, is catabolized to quinolinic acid, to generate NAD +

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Additionally, NR treatment led to improved health and lifespan in the same animal models 111,288