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This design additionally enables prolonged circulation time and controlled release of the therapeutic agent, ultimately achieving precise delivery to tau-related Alzheimer's pathological lesions in AD mice (Zhou et al., 2020)

Following GA administration, liver TG and cholesterol levels were reduced, d fatty acid levels decreased, the ratio of PUFA to MUFA increased, and the levels of ALT and AST decreased significantly

Bioorganic & Medicinal Chemistry Letters .

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To reduce clearance and increase the serum half-life, polyethylene glycol-5000 (PEG5000) was conjugated to the molecule