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With growing insights into trained immunity, several classical vaccines have been shown to induce long-lasting functional reprogramming of innate immune cells, resulting in enhanced nonspecific protection upon subsequent infections

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Severe Acne: characterized by nodules, large, painful, solid lesions that appear as lumps under the skin, and cysts, deep, inflamed, pus-filled lesions that can be very painful

BZ: Data curation, Formal Analysis, Writing original draft