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doi: 10.1038/s41598-017-10734-y 147 WanetA.ArnouldT.NajimiM.RenardP

The reactive SH group of glutathione can form a thioether by reacting with C=C double bonds, carbonyl groups or other reactive groups forming a glutathione conjugate

Vitamin C works hand in hand with glutathione

RSL3 is known to interact with thioredoxin reductase 1 (Txnrd1) which also plays a role in DNA damage and oxidative stress 31

A significant increase in hepatic STAT3 phosphorylation and acetylation and binding of FXR to Stat3 promoter, as well as decreased apoptosis markers by flow cytometry (FAS, caspase 8 and caspase 3), were present in FXR agonist/DDC mice compared to DDC mice

Therefore, further elucidating the pathogenesis of RA and identifying new therapeutic targets will help develop more personalized, effective, and safe treatment approaches, thereby improving the quality of life of RA patients and reducing the socioeconomic burden of the disease