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About 2% oxygen is used by the mitochondria to generate , and thus this organelle is considered as the main source of ROS and this through multiple pathways (Murphy, 2009)

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Patients with stable schizophrenia had significantly lower scores on the ACC glutathioneglutamate component, an effect almost entirely leveraged by the sub-group of patients with residual schizophrenia

A2780DPP cells were therefore transfected with shRNA constructs 775 and 776, optimised for GSTP1 knockdown in the experiments described above

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