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Taken together, the above discussion is consistent with the notion that although further studies are needed to better understand the cross talk between OS and tau phosphorylation/dephosphorylation, a close interplay exists that suggests that these events are key components of a vicious circle that plays a crucial role in tau pathology in AD

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AGE formation Endogenous AGEs Endogenous AGEs represent adducts that are produced and slowly accumulated within the body during the normal aging process and under the oxidative stress, inflammatory, and hyperglycemic (high blood sugar) conditions often observed in diabetes and other metabolic syndromes 1,4,12,13

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