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Common causes of knee pain include: Osteoarthritis : The most frequent culprit, where cartilage gradually breaks down over time Meniscus tears : Damage to the shock-absorbing cartilage in your knee Tendinosis : Chronic degeneration of tendons around the knee Ligament injuries : Sprains or tears in the supportive structures Inflammatory conditions : Including rheumatoid arthritis and lupus Referred pain : Sometimes hip problems can cause knee discomfort Traditional treatments typically involve anti-inflammatory medications, physical therapy, steroid injections, or in severe cases, surgery

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Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, Druzijancic N, et al

doi:10.1177/23259671241308854 Monson JK, Tollefson L V., LaPrade CM, LaPrade RF

Neither has been tested in humans, and both carry significant unknowns -- Dihexa with its retracted publication and oncological pathway concerns, PE-22-28 with its untested cognitive effects and potential seizure susceptibility