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An alternative oxidative pathway for EE that has been identified is removal of the ethinyl group (from EE or its metabolites), which then renders E1 or E2 metabolites, with significant formation of 2-hydroxyestrogens 34

GSTs, in turn, conjugate GSH to xenobiotics in a first step of detoxification 53,54

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This relationship was also significant for each patient subgroup individually (hypertensives: r =0.64, P =0.002