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These findings matter because the tobacco industry routinely targets young people in an effort to create lifelong smokers

Nicotine fulfills all the criteria of an addictive agent, including psychoactive effects, drug-reinforced behavior, compulsive use, relapse after abstinence, physical dependence, and tolerance

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Also encouraging continued cigarette use is the desire to avoid cigarette withdrawal symptoms, such as irritability, depressed mood, restlessness, anxiety, and somatic symptoms, which can begin as little as 20 min after smoking but generally peak around 2 h [6, 8]

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The Downsides of Nicotine Itself Even when using the cleanest delivery methods, the nicotine molecule is not harmless