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NFE2L2/NRF2 Activity Is Linked to Mitochondria and AMP-Activated Protein Kinase Signaling in Cancers through MIR-181c/Mitochondria-Encoded Cytochrome C Oxidase Regulation

2.4 Statistical analysis We used R (version 4.1.2, R Foundation for Statistical Computing, Vienna, Austria) for data analysis and figure plotting

Nitric Oxide (2023) 130:2235

2025;6:e70152

We further examined the involvement of the aryl hydrocarbon receptor (AHR), a primary target of TRP metabolites, and similarly found that AHR KO did not impair 3-HK-mediated FTH1/FTL upregulation (Extended Data Fig