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10.1186/s40360-018-0204-7 139 LaleuB.GagginiF.OrchardM.Fioraso-CartierL.CagnonL.Houngninou-MolangoS.et al (2010)

39 Other cases have been reported with severe PFIC in homozygous ABCB4 mutations in children born to consanguineous parents

Front Immunol (2018) 9:1961

Collection Ordering Result Interpretation Administrative Collect Preferred: 2mL Blood collected in EDTA tube

Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)