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Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis

Two severe adverse events were reported: viral meningitis (in cagrilintide 1.2 mg + semaglutide 2.4 mg) and an increase in serum creatinine (in placebo + semaglutide 2.4 mg), but both events were deemed unrelated to study treatment by the study investigator

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Measurement of ROS Production ARPE-19 Cells (5,000/well) were seeded in white opaque 96-well plates (Corning, Sigma-Aldrich) and incubated overnight