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Importantly, there was also evidence of increased transsulfuration pathway activation by MYCN

10.1161/01.cir.34.5.910 312 StroobandtR.DodionL.KestelootH

Gene panels inevitably exclude variants in genes that may be relevant for a given phenotype, whereas WES provides the ability to analyze additional variants in coding regions as required

However, these values should be cautiously interpreted