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433 The adipocytes of Friedreichs ataxia mice showed significantly reduced GPX4 expression, increased lipid peroxides, and significantly increased sensitivity to ferroptosis

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Simultaneously, anti-inflammatory cytokines such as TGF-, GDF-5, GDF-6, IL-4, and IL-10 are also present in the degenerative environment and can, to some extent, delay degeneration and alleviate pain (Wang et al., 2016), with their balance potentially closely related to the polarization state of macrophages (Yamamoto et al., 2022

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Semaglutide and tirzepatide are "upstream" they act on incretin receptors to influence appetite regulation, gastric emptying, and glucose-dependent insulin secretion

These and other findings have led to the currently predominant view of ROS as important signaling molecules