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The ERGIC can then serve as a membrane source for LC3 lipidation, which is dependent on the adaptor protein WIPI2 and ATG5 but does not require ULK1 or VPS34, indicating that this non-canonical STING-dependent induction of autophagy can skip early steps of the canonical autophagy mechanism (141)

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Additionally, isotope tracing studies have demonstrated that lactate functions as a major fuel in the TCA cycle, where 13C-lactate labeled TCA intermediates in every tissue of the body, even in tumors (31,32)

Genetic Single Nucleotide Polymorphisms (SNPs): Certain genetic variations are associated with inhibited DAO activity