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reported that lactate can promote angiogenesis and reperfusion in ischemic wounds in mice, indicating that lactate induces healing angiogenesis [166]

Despite its documented efficacy in vitro and in vivo in alleviating oxidative stress and preventing iron deficiency, Fer-1 remains untested in clinical trials (114)

N-Isobutyrylcysteine, a thiol designed to deliver more free thiol than NAC does, was tested against placebo in 637 individuals with COPD for 6 months, and found to have no effect on respiratory exacerbations

This increases the release of cholesterol and cholesteryl esters and impairs CD8 + T cell activity in the TME [128]

Furthermore, estrogens have anabolic, insulinotropic, and anorectic effects (157)

Ethics declarations Conflict of interest The authors declared no conflict of interest