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Nrf2/HO-1 inhibition exacerbates oxidative stress and iron dysregulation, leading to iron deficiency in PH

Left panel: Soman, a G-series organophosphate nerve agent first synthesized in 1944, irreversibly inhibits AChE after rapid aging of the enzymeagent complex

doi: 10.1111/hepr.12431 53 NobusawaAKimMKairaKMiyashitaGNegishiAOriuchiNet al

[80] found that NAC can function to reduce heroin-seeking behavior in rodent models, potentially demonstrating another beneficial mechanism with regard to postoperative opioid consumption and concern for new persistent opioid use and abuse