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With age, this collagen matrix undergoes two damaging processes: decreased synthesis and increased degradation

Enhanced angiogenesis counters the reduced vascularization typical in diabetic tissue

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Recovery-associated signaling pathways

In vitro promotion of cell proliferation, migration and angiogenesis effects of the G/D-CuP The formation of new blood vessels, called angiogenesis, is a crucial event during the proliferation stage of wound healing, and poor vascularization contributes to the delayed healing of diabetic wounds