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Description

K.HarbourtD

Pirazzi, C

Neuron 109 , 31043118.e6 (2021)

As a result its biologic activity is normally completely inactivated when orally ingested because of its very low bioavailability

Chronic obstructive pulmonary disease (COPD) induces dynamic hyperinflation, increases intrathoracic pressure (ITP) and PVR, compresses the LV and reduces stroke volume via direct ventricular interaction (DVI), a mechanical constraint worsened by the loss of elastic recoil in emphysema