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Simultaneous administration of carbamazepine in a daily dose 400 mg resulted in a decrease in plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine to 76% and 60%, respectively

These symptoms are usually short-lived, resolving within 24 to 72 hours

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The review documented DSIP's widespread distribution throughout the brain and peripheral tissues, its remarkably stable presence in cerebrospinal fluid, and its unusually long-lasting biological effects despite a short plasma half-life of only minutes