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The N-Ethyl-N-Nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

This macrophage reprogramming is associated with SFN-mediated inhibition of the transcription factor c-Myc, which normally drives M2 polarization, and concurrent activation of the Nrf2 pathway that favors M1-associated gene expression profiles (78)

doi: 10.1186/s12970-015-0067-x

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