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Upon migration to peripheral tissues, monocytes differentiate into either dendritic cells or macrophages

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Mfn2 is regulated by metabolic factors such as obesity and type II diabetes, inflammatory factors such as TNF- and interleukin 6, as well as other oxidative and hormonal signals

Lipofuscin Lipofuscin is an age-related pigment that accumulates in RPE and keratinocytes, as well as in cardiac and neuronal tissues, under both physiological and pathological conditions 84,85,86

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