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21 RANK-L activation results in osteoclast formation which is the main mediator of joint damage and destruction

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However, this idea, while demonstrating the ameliorative effect of vagus nerve excision on the association with obesity (101), is limited by the absence of significant changes in some lean animals and some populations (98), as well as the increased occurrence of secondary trauma and mortality after excision (102)

PMID 12322757

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For glutathione to do its job as an antioxidant, it must be in the reduced state