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Intriguingly, other studies report no change in fibroblast responsiveness with age [165]

While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

To better mimic the native tumor microenvironment, 3D cultures can employ extracellular matrix materials [167], hydrogels, microfiber scaffolds, tissue engineering [168], co-cultures [158, 166, 167, 169] and can even make use of 3D bioprinting [170]

Marco-Contelles, 2024)

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Secondary endpoints in trials include reductions in waist circumference , visceral fat mass, appetite scores, and daily caloric intake