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10.1371/journal.pgen.1004279 PLoS Genet

Liu Z, Wu C, Lin Z, Li H, Liu Y, Amjad N, et al

These detailed cascades, while well-documented in the cited literature, are proposed as hypothetical frameworks to explain the functional consequences of the target downregulation we observed, and they require direct experimental confirmation in the context of palmatine treatment

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For example, the bioavailability of quercetin in humans after oral administration was as low as 1%, which was attributed to poor aqueous solubility (2.84 mg/mL)