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Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects

Mov Disord 29(2):229237 Bianchini E, Sforza M, Rinaldi D, Alborghetti M, De Carolis L, Della Gatta F et al (2021) Switch from rasagiline to safinamide in fluctuating Parkinsons disease patients: a retrospective, pilot study

While the inhibition of MAO-A in the brain is necessary for an antidepressant effect, inhibition of both MAO-A and MAO-B provides a greater increase in serotonin, norepinephrine, and dopamine than inhibition of either MAOI isomer alone (Figure 1A and B).27,29 Theoretically, inhibition of both MAO-A and MAO-B can lead to greater increases of each neurotransmitter compared with inhibition of either isoenzyme alone

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Herein, we provide evidence that hepatic GSSG accumulation, which was observed in a high-fat diet (HFD)-fed model of NAFLD, rendered hepatocytes susceptible to TNF-induced cell death