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Compared to cyanocobalamin, it is characterised by a stronger binding to tissue and serum proteins, which means a delayed excretion with the urine and thus a longer availability for absorption into the tissue stores

Methylcobalamin is generally considered the fastest acting because it is already in an active form and does not require conversion

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Activation, Differential Localization, and Regulation of the Stress-Activated Protein Kinases, Extracellular Signal-Regulated Kinase, C-JUN N-Terminal Kinase, and P38 Mitogen-Activated Protein Kinase, in Synovial Tissue and Cells in Rheumatoid Arthritis